Effect of aqueous fruit extract of Emblica officinalis on haloperidol induced catalepsy in albino mice.

Pemminati, Sudhakar and *, V Nair and *, Dorababu.P and *, Gopalakrishna HN and Pai , MRSM (2009) Effect of aqueous fruit extract of Emblica officinalis on haloperidol induced catalepsy in albino mice. Journal of Clinical and Diagnostic Research, 3 (4). pp. 1657-1662. ISSN 0973-709X

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Neuroleptic drugs used in the treatment of schizophrenia and other affective disorders are known to produce extrapyramidal side effects. Catalepsy was induced by these drugs in animals and these have been used as models for the extrapyramidal side effects associated with antipsychotic agents in human beings. In the present study, we have attempted to evaluate the protective effect of the aqueous extract of the fruits of Emblica officinalis (EO) on haloperidol (1.0mg/kg intraperitoneal administration) induced catalepsy in mice by employing the standard bar test. Mice were allocated to seven groups, each group containing six animals. The effects of the test drug EO (0.8, 2.0 and 4.0mg/kg doses) and the standard drugs scopolamine (1.0mg/kg) and ondansetron (0.5 and 1.0mg/kg doses) were assessed after single and repeated dose administration for seven days, 30 minutes prior to the haloperidol. Mice were sacrificed on the seventh day and super oxide dismutase (SOD) activity in the brain tissue was estimated by using the Beauchamp and Fridovich method. A significant (P<0.001) reduction in the cataleptic scores was observed in all the test drug treated groups as compared to the control, with maximum reduction in the dose 4.0mg/kg group. Similarly, the maximum reduction in SOD activity (P<0.01) was observed in the dose 4.0mg/kg group. Our study suggests that EO has significantly reduced oxidative stress and the cataleptic score induced by haloperidol. It could be used to prevent drug- induced extrapyramidal side effects.

Item Type: Article
Additional Information: Key message: Neuroleptics (antipsychotic drugs) are usually associated with extrapyramidal side effects. The mice were treated by standard drugs like scopolamine or centrally acting anticholinergics; but these have many side effects like dryness of mouth, blurred vision etc. Emblica officinalis is a commonly available fruit in India. It was the best alternative to treat the extrapyramidal side effects induced by neuroleptics
Uncontrolled Keywords: Emblica officinalis, haloperidol , catalepsy
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 04 Jan 2012 10:17
Last Modified: 04 Jan 2012 10:17
URI: http://eprints.manipal.edu/id/eprint/1889

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