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Expression of e-cadherin in primary oral squamous cell carcinoma and metastatic lymph nodes:an immunohistochemical study

Kaur, Gurkiran and Carnelio, Sunitha and Rao, Nirmala and Rao, Laxmi (2009) Expression of e-cadherin in primary oral squamous cell carcinoma and metastatic lymph nodes:an immunohistochemical study. Indian J Dent Res, 20 (1).

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Abstract

Background: E-cadherin plays an important role in cell-to-cell adhesion and cell motility and its loss is associated with oral squamous cell carcinoma (OSCC) progression. The aim of this study was to determine the expression of E-cadherin in various grades of OSCC and to correlate changes in the expression between these various grades and metastatic lymph nodes. Materials and Methods: Immunohistochemistry (IHC) was used to detect E-cadherin expression in normal oral mucosa, primary OSCC ( n = 37), and metastatic lymph nodes ( n = 10). E-cadherin immunoreactivity was correlated with grades of differentiation and with clinicopathological features. Results: E-cadherin immunoreactivity was found to inversely correlate with the loss of cell differentiation. The expression of E-cadherin decreased significantly in advanced cases of OSCC. However, increase in E-cadherin immunoreactivity was seen in early lesions, that is, in well differentiated ( n = 9) and moderately differentiated OSCC ( n = 13). Furthermore, E-cadherin was negative in majority of metastatic lymph nodes (7/10). Conclusions: Loss of the cell adhesion and E-cadherin plays an important role in progression of OSCC, that is, down regulation of its expression is associated with de-differentiation and metastasis.

Item Type: Article
Uncontrolled Keywords: Cell adhesion molecules, E-cadherin, immunohistochemistry, lymph nodes, squamous cell carcinoma
Subjects: Dentistry > MCODS Manipal > Oral and Maxillofacial Surgery
Depositing User: KMC Manipal
Date Deposited: 27 Dec 2011 04:33
Last Modified: 27 Dec 2011 04:33
URI: http://eprints.manipal.edu/id/eprint/1981

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