Comparison of neutrophil functions in diabetic and healthy subjects with chronic generalized periodontitis

Shetty, Neetha and Thomas, Biju and *, Amita Ramesh (2008) Comparison of neutrophil functions in diabetic and healthy subjects with chronic generalized periodontitis. Journal of Indian Society of Periodontology, 12 (2). pp. 41-44.

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Abstract

Background : Diabetes mellitus is a systemic condition that has long been associated with an increased risk and severity of periodontal disease. Polymorphonuclear leukocytes (PMNs) play a key role in the maintenance of gingival and periodontal health. Reduced PMN function has been found in patients with diabetes. Aim: The objective of this study was to evaluate PMN functions in 15 diabetic patients with chronic generalized periodontitis. Materials and Methods: Chemotaxis, superoxide production, phagocytosis and killing of Porphyromonasgingivalis by diabetic PMNs were evaluated relative to healthy and matched controls. Results: These analyses revealed a significant (P < 0.01) depression in the number of diabetic PMNs migrating along an fMLP gradient. In addition, a significant (P < 0.01) enhancement of diabetic PMN superoxide production was observed. Phagocytosis (P < 0.05) and killing by diabetic PMN of P. gingivalis was also impaired significantly (P < 0.01).

Item Type: Article
Uncontrolled Keywords: Diabetes mellitus, periodontitis, polymorhonuclear leukocytes
Subjects: Dentistry > MCODS Mangalore > Periodontics
Depositing User: KMCMLR User
Date Deposited: 04 Jan 2012 10:11
Last Modified: 04 Jan 2012 10:11
URI: http://eprints.manipal.edu/id/eprint/1986

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