Synthesis and biological evaluation of aminoketones

Rai, Sankappa U and Isloor, Arun M and Shetty, Prakash and Isloor, Nishitha and Malladi, Shridhar and Fun, Hoong-Kun (2010) Synthesis and biological evaluation of aminoketones. European Journal of Medicinal Chemistry, 45 (12). pp. 6090-6094. ISSN 0223-5234

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A three-component Mannich reaction of different ketones with aromatic aldehydes and different amines in microwave irradiation under solvent free condition afforded corresponding b-amino carbonyl compounds in excellent yields. This method proved as a novel and improved modification of the reported three-component Mannich reaction in terms of milder reaction conditions, reaction times, clean reaction profiles, very small quantity of catalyst and simple workup procedure. Newly synthesized b-aminoketones were characterized by spectral studies. Structure of compound 4a was also confirmed by singlecrystal X-ray analysis. All the compounds were screened for their antimicrobial activity by MIC method. Few of the molecules were found to be biologically potent.

Item Type: Article
Additional Information: © Elsevier Masson SAS
Uncontrolled Keywords: b-aminoketones CeCl3 Synthesis Antimicrobial activity Microwave reaction
Subjects: Engineering > MIT Manipal > Chemistry
Engineering > MIT Manipal > Printing and Media
Depositing User: MIT Library
Date Deposited: 10 Jan 2012 10:39
Last Modified: 10 Jan 2012 10:39

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