Rathore, Padmini and Hegde, Ashwini and Ginjupalli, Kishore and Upadhya, Nagaraja P (2009) Evaluation of Antifungal Activity of Additives to Resilient Liners: An in vitro Pilot Study. Trends Biomater. Artif. Organs,, 23 (1). pp. 6-9.

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Abstract

Colonization of microorganisms in resilient liners is one of the main causes of denture stomatitis. Candida albicans is the most widely isolated organism during denture stomatitis. Use of resilient liners with antifungal activity can be of great help for such patients. Aim of the present in vitro study is to evaluate the antifungal activity of copper sulfate, borax and chlorhexidine mixed with resilient liner. Lawn cultures of candida albicans were prepared on Sabouraud’s dextrose agar. Wells were punched into these cultures and filled with resilient liner containing 0.5 w/v% of Copper sulfate or a combination of equal amounts of copper sulfate and borax in 0.5 w/v% or 2 w/v% of chlorhexidine. Plates were incubated at 37 °C and Mean Inhibitory Zone (MIZ) was measured at 24 and 72 hours. Resilient liner added with copper sulfate had shown maximum MIZ at 24 and 72 hours. Among the additives used, chlorhexidine had shown least antifungal activity.

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