Novel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents

Rai, Sankappa and Isloor, Arun M and Shetty, Prakash and Vijesh, A M and Prabhu, Nithin and Isloor, Shrikrishna and Thiageeswaran, M and Fun, Hoong-Kun (2010) Novel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents. European Journal of Medicinal Chemistry, 45 (6). pp. 2695-2699. ISSN 0223-5234

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Abstract

An efficient, microwave irradiated synthesis of novel chromeno[2,3-b]-pyrimidine derivatives was carried out. 2-Amino-3,4-dihydro-2H-chromene-3-carbonitrile was converted into imine using N,N-Dimethylacetaldehyde dimethylacetal to give the core intermediate, which was used for the preparation of chromenopyrimidine library, using acetic acid and different amine in microwave irradiation for 5 min. Structures of newly synthesized compounds were confirmed by spectral studies. Compound 6g was characterized by single crystal X-ray analysis. All the compounds were also screened for their antimicrobial activity. Few of the compounds are found to be potential antimicrobials.

Item Type: Article
Uncontrolled Keywords: Chromeno[2,3-b] pyrimidine Chromene-3-carbonitrile Antimicrobial study
Subjects: Engineering > MIT Manipal > Chemistry
Engineering > MIT Manipal > Printing and Media
Depositing User: MIT Library
Date Deposited: 11 Jan 2012 03:42
Last Modified: 11 Jan 2012 03:42
URI: http://eprints.manipal.edu/id/eprint/2097

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