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Preimplantation diagnosis of genetic diseases

Adiga, Satish Kumar and Kalthur, Guruprasad and Kumar, P and Girisha, KM (2010) Preimplantation diagnosis of genetic diseases. Journal of Postgraduate Medicine, 56 (4). pp. 317-320. (Submitted)

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Abstract

One of the landmarks in clinical genetics is prenatal diagnosis of genetic disorders. The recent advances in the field have made it possible to diagnose the genetic conditions in the embryos before implantation in a setting of in vitro fertilization. Polymerase chain reaction and fluorescence in situ hybridization are the two common techniques employed on a single or two cells obtained via embryo biopsy. The couple who seek in vitro fertilization may screen their embryos for aneuploidy and the couple at risk for a monogenic disorder but averse to abortion of the affected fetuses after prenatal diagnosis, are likely to be the best candidates to undergo this procedure. This article reviews the technique, indications, benefits, and imitations of preimplantation genetic testing in clinical practice.

Item Type: Article
Uncontrolled Keywords: Pre-implantation diagnosis, genetics, prenatal diagnosis
Subjects: Medicine > KMC Manipal > Obstetrics & Gynaecology
Depositing User: KMC Manipal
Date Deposited: 02 Jan 2012 10:57
Last Modified: 04 Nov 2016 14:21
URI: http://eprints.manipal.edu/id/eprint/2129

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