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Effect of Eugenia Jambolana on Plasma Glucose, Insulin Sensitivity and HDL-C Levels: Preliminary Results of A Randomized Clinical Trial

*, Sahana D.A and *, Shivaprakash G and Baliga, Raghavendra and *, Adhikari Prabha M.R and *, Jyothi Ganesh and Pai, M.R.S.M (2010) Effect of Eugenia Jambolana on Plasma Glucose, Insulin Sensitivity and HDL-C Levels: Preliminary Results of A Randomized Clinical Trial. Journal of Pharmacy Research, 3 (6). pp. 1268-1270.

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Abstract

To validate scientifically a household remedy of Eugenia jambolana seed based drug Madhuhara churna [AVA Trust Regd] in diabetes mellitus, a use based on ethnic preferences. A 6 month parallel designed open labeled randomized, controlled trial was conducted in 30 newly diagnosed type 2 diabetes mellitus. Patients were enrolled to: Group 1 (n = 15) received Madhuhara churna [AVA Trust Regd]; Group 2 (n= 5) received metformin and Group 3 (n=10) were on diet restriction and exercise therapy only. They were followed up each month for 6 months with detailed clinical examination; assessment of compliance to drug intake, diet adherence and exercise; a complete history of adverse events; different parameters to measure the efficacy were done. There was no significant difference in the baseline characteristics of patients in each of the three groups enrolled for study. The results showed a significant decrease in fasting blood glucose at 3rd (152.0 mg/dl± 22.5 to 140.7 mg/dl± 26.6, P=0.016) and 6th (152.0 mg/dl± 22.5 to 134.0 ± 21.3, P=0.043) month, homeostatic model assessment for insulin resistance at 3rd (10.3 ± 4.7 to 6.5 ± 4.1, P=0.027) month and a highly significant rise in high density lipoprotein value at 3rd (39.7 ± 9.6 to 47.3 ± 6.8, P= 0.001) month was seen in group 1 when compared to baseline values. Madhuhara churna [AVA Trust Regd] treatment in type 2 diabetic patients for 6 months has a beneficial effect in improving the glycemic profile in newly diagnosed type 2 diabetics.

Item Type: Article
Uncontrolled Keywords: Eugenia jambolana; Fasting blood glucose; Homeostatic model assessment; Glycosylated hemoglobin; Diabetes mellitus
Subjects: Medicine > KMC Mangalore > Pharmacology
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 04 Jan 2012 06:01
Last Modified: 04 Jan 2012 06:01
URI: http://eprints.manipal.edu/id/eprint/2145

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