MU Digital Repository
Logo

Efficacy and tolerability of trandolapril in mild to moderate hypertension - a double blind comparative clinical trial with enalapril in Indian population

Pinakini, Shankar K and Vidyasagar, Sudha and Adiga, Sachidananda and Naidu, MUR and Usha Rani, P and Rao, Dayasagar and Bairy, KL and Nair, Sreekumaran N and Jayaprakash, B and Shashikiran, U and Prabhu, Mukhyaprana (2006) Efficacy and tolerability of trandolapril in mild to moderate hypertension - a double blind comparative clinical trial with enalapril in Indian population. Indian J Physiol Pharmacol, 50 (4). pp. 421-426.

[img] PDF
EFFICACY_AND_TOLERABILITY_OF_TRANDOLAPRIL_IN_MILD_TO.pdf - Published Version
Restricted to Registered users only

Download (28kB) | Request a copy

Abstract

Several large scale clinical trials have demonstrated that angiotensin converting enzyme inhibitors offer cardiovascular and renal protection independent of their effects on systolic BP. Trandolapril is a new angiotensin converting enzyme inhibitor approved for the treatment of hypertension. The potential advantages of this drug are long duration of action and better tolerability. The objective of the study was to compare the efficacy and tolerability of trandolapril with that of enalapril in mild to moderate hypertension in Indian population. In this double blind, multicentric, parallel comparative clinical study, 120 patients with mild to moderate hypertension were randomly assigned to receive trandolapril 2 mg or enalapril 5 mg once daily for 8 weeks. The attainment of sitting diastolic blood pressure <90 mmHg at the end of 8th week was considered as primary outcome measure and attainment of diastolic blood pressure <90 mmHg or reduction of at least 10 mmHg diastolic blood pressure compared to baseline at any visit was considered as secondary outcome measures. 98.4% patients treated with trandolapril and 92.6% patients treated with enalapril fulfilled the primary outcome measure. 54, 72 and 62% patients on trandolapril and 52, 61 & 64% patients on enalapril fulfilled secondary outcome measure at the end of 2nd, 4th and 8th week respectively. Also trandolapril was better tolerated than enalapril with no significant abnormality in lab parameters.

Item Type: Article
Uncontrolled Keywords: tandolapril, efficacy , safety , hypertension.
Subjects: Medicine > KMC Manipal > Medicine
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 04 Jan 2012 04:58
Last Modified: 05 Nov 2016 14:54
URI: http://eprints.manipal.edu/id/eprint/2182

Actions (login required)

View Item View Item