Formulation and in Vitro Evaluation of Floating Pulsatile Tablets of Nizatidine for Chronotherapy of Ulcers

Rathnanand, Mahalaxmi and Pannala, Srinivas (2011) Formulation and in Vitro Evaluation of Floating Pulsatile Tablets of Nizatidine for Chronotherapy of Ulcers. Journal of Pharmacy Research, 4 (5). pp. 1388-1390.

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Abstract

The objective of the present work is to formulate and evaluate (in vitro) floating pulsatile tablets of Nizatidine, a H2 receptor antagonist, which conceptualizes a specific technology, based on combining principles of both the floating and pulsatile principles to deliver a programmed dose of drug from the developed delivery system anticipated for chronotherapy of excessively secreted gastric acid and for promoting healing of duodenal ulcers. Accordingly floating pulsatile Nizatidine tablets were developed in three different steps viz, preparation of immediate release drugcontaining core tablets, time-lagged film coating by a hydrophobic rupturable polymer, ethyl cellulose (EC), and compression coating of a buoyant layer using gel forming polymers like carbopol 934P, poly(ethylene oxide) and sodium bicarbonate for the generation of carbon dioxide which is responsible for the floating behavior of the tablet on the gastric contents. The obtained tablets were evaluated for weight variation, thickness, hardness, disintegration, in vitro floating properties (buoyancy studies) and in vitro dissolution studies. Stability studies of the optimized formulation was carried out as per ICH guidelines at 40 ± 2oC / 75 ±5% RH for one month and it was found to be stable.

Item Type: Article
Uncontrolled Keywords: Floating pulsatile delivery systems, Chronotherapy, wet granulation, Compression coating.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 04 Jan 2012 09:38
Last Modified: 04 Jan 2012 09:38
URI: http://eprints.manipal.edu/id/eprint/2196

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