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Toxicity prediction of compounds from turmeric (Curcuma longa L)

Balaji, S and Chempakam, B (2010) Toxicity prediction of compounds from turmeric (Curcuma longa L). Food and Chemical Toxicology, 48 (10). pp. 2951-2959.

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Abstract

Turmeric belongs to the ginger family Zingiberaceae. Currently, cheminformatics approaches are not employed in any of the spices to study the medicinal properties traditionally attributed to them. The aim of this study is to find the most efficacious molecule which does not have any toxic effects. In the present study, toxicity of 200 chemical compounds from turmeric were predicted (includes bacterial mutagenicity, rodent carcinogenicity and human hepatotoxicity). The study shows out of 200 compounds, 184 compounds were predicted as toxigenic, 136 compounds are mutagenic, 153 compounds are carcinogenic and 64 compounds are hepatotoxic. To cross validate our results, we have chosen the popular curcumin and found that curcumin and its derivatives may cause dose dependent epatotoxicity. The results of these studies indicate that, in contrast to curcumin, few other compounds in turmeric which are non-mutagenic, non-carcinogenic, non-hepatotoxic, and do not have any side-effects. Hence, the cost-effective approach presented in this paper could be used to filter toxic compounds from the drug discovery lifecycle.

Item Type: Article
Additional Information: Copyright © 2010 Elsevier Ltd.
Uncontrolled Keywords: Turmeric;Toxicity;Mutagenicity;Carcinogenicity;Hepatotoxicity
Subjects: Engineering > MIT Manipal > Biotechnology
Depositing User: MU Library
Date Deposited: 19 May 2011 08:16
Last Modified: 19 May 2011 08:16
URI: http://eprints.manipal.edu/id/eprint/22

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