Nayak, Ravi Kumar and Narayana Swamy, VB and Dave, Mehul and Senthil, A and Lad, Tejas and Mahalaxmi, R (2011) Formulation And Evaluation of Sustained Release Matrix Tablets of Iornoxicam. Indo-Global Research Journal of Pharmaceutical Sciences, 1 (3). pp. 92-99.

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Abstract

The main objective of the present investigation was to develop sustained release matrix tablets of lornoxicam using different natural polymers viz. Guar gum, xanthan gum, Rosin, Sodium alginate and pectin. Varying ratios of drug and polymer like 1:1 and 1:2 were selected for the study. The tablets were evaluated for physical characteristics like hardness, weight variation, fraibilty and drug content. All the physical characters of the fabricated tablet were within acceptable limits. In-vitro release of drug was performed in PBS pH 6.8 for 24 h. The DSC and FTIR study revealed that there was no chemical interaction between drug and excipients. The tablet with guar gum (F10) in the ration of drug: polymer (1:2) exhibited greater swelling index and better dissolution profile than those with pectin, xanthan gum, sodium alginate and pectin. Based on the evaluation results, F10 formulation was selected as the best formulations and was checked for stability as per ICH guidelines. These results indicated that the selected formulation was stable. The drug release profile of the best formulation was well controlled and uniform throughout the dissolution studies. The drug release of optimized formulation follows the Higuchi kinetic model, and the mechanism is found to be non-Fickian/anomalous according to Korsmeyer–Peppas equation.

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