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Enhancement of Solubility And Dissolution of Poorly Soluble Drug: Ketoprofen as a Model Drug

Amit, K and Mahalaxmi, R and Srinivas, P and Deepak, K (2011) Enhancement of Solubility And Dissolution of Poorly Soluble Drug: Ketoprofen as a Model Drug. Journal of Chemical and Pharmaceutical Research, 3 (1). pp. 268-276. (Submitted)

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Abstract

The objective of the study was to formulate micro particles of a poorly soluble drug Ketoprofen with the aid of Chitosan in presence of salting out agents. Dissolution Studies were carried out in 0.1N HCl using USP type II dissolution apparatus. The effect of Chitosan in presence of salting out agent predominated drug dissolution rate with the increasing concentrations of chitosan. A decrease in dissolution rate can be explained based on the viscous gel formation by chitosan at higher concentration (above 0.4%). The fine and fluffy physical state of optimized formulation along with their porous and rough surface as supported by SEM photomicrographs might have contributed to the enhanced solubility and dissolution rate of ketoprofen. Accelerated stability studies were performed as per ICH guidelines.

Item Type: Article
Uncontrolled Keywords: Microparticles, High dispersion homogenizer, salting out agents, Carrageenaninduced paw edema, ICH guidelines.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 04 Jan 2012 05:46
Last Modified: 04 Jan 2012 05:46
URI: http://eprints.manipal.edu/id/eprint/2203

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