Nayak, RK and Manjunath, B and Narayana Swamy, VB and Senthil, A and Thakkar, HK and Kumar, DM and Mahalaxmi, R (2011) Design and Evaluation of Sustained Release Floating Tablets of Loratadine. Asian Journal of Biochemical and Pharmaceutical Research, 3 (1). pp. 2231-2560.
![]() |
PDF
p11.pdf - Published Version Restricted to Registered users only Download (320kB) | Request a copy |
Abstract
Loratadine used for the symptomatic relief of allergic conditions such as runny nose, itchy or watery eyes, sneezing, and nasal or throat itching and chronic urticaria for many decades. The present investigation concerns the development and evaluation of floating tablets of loratadine which, after oral administration, are designed to prolong the gastric residence time, increase drug bioavailability. A floating drug delivery system (FDDS) was developed using gas-forming agents, like sodium bicarbonate, citric acid and hydrocolloids, like hydroxypropyl methylcellulose (HPMC) and carbopol 934P. The prepared tablets were evaluated in terms of their precompression parameters, physical characteristics, in vitro release, buoyancy, buoyancy lag-time and swelling index. The formulations were optimized for the different viscosity grades of HPMC, carbopol 934P and its concentrations and combinations. The results of the in vitro release studies showed that the optimized formulation (F12) could sustain drug release (98%) for 24 h and remain buoyant for 24 h. The optimized formulation was subjected to various kinetic release investigations and it was found that the mechanism of drug release was predominantly diffusion with a minor contribution from polymeric relaxation. Optimized formulation (F12) showed no significant change in physical appearance, drug content, total buoyancy time or in vitro dissolution study after storage at 40°C/75% RH for three months. Finally the tablet formulations found to be economical and may overcome the draw backs associated with the drug during its absorption.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | Loratadine, Floating drug delivery system, Hydrocolloids, Gastric residence time, In vitro dissolution study. |
Subjects: | Pharmacy > MCOPS Manipal > Pharmaceutics |
Depositing User: | KMC Manipal |
Date Deposited: | 04 Jan 2012 06:30 |
Last Modified: | 04 Jan 2012 06:30 |
URI: | http://eprints.manipal.edu/id/eprint/2216 |
Actions (login required)
![]() |
View Item |