Development and Characterization of Orodispersible Tablets of Loratadine Using Sublimation Technique

Nayak, Ravi Kumar and Manjunath, B and Narayana Swamy, VB and Senthil, A and Thakkar, Hardikkumar and Dave, Mehul Kumar and Mahalaxmi, R (2011) Development and Characterization of Orodispersible Tablets of Loratadine Using Sublimation Technique. Asian Journal of Biochemical and Pharmaceutical Research, 3 (1). pp. 2231-2560. (Submitted)

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The aim of the present research work is to evaluate the impact of subliming agents in the formulation and evaluation of rapidly disintegrating tablets. In the present study, Loratadine is the model drug. Rapidly disintegrating tablets of Loratadine were prepared using different proportions of camphor, menthol, thymol and ammonium bicarbonate as subliming agent and crosspovidone as superdisintegrant. The formulations were evaluated for weight variation, hardness, friability, drug content, wetting time, in vitro and in-vivo dispersion, mouth feel and in vitro dissolution. Tablets with menthol at 12.5% concentration have shown quick disintegrating features, i.e., within 20 s, which is very characteristic of oro-dispersible tablets. The in vitro drug release study revealed that menthol at a concentration of 12.5 % (F10) of the dosage form weight was able to fast the release of Loratadine within 10 minutes. These compressed tablets which have 12.5 % menthol (F10) rapidly dissolved within 25 seconds in saliva in the mouth. Further optimized formulations (F10) were subjected to stability testing for 3 months at temperatures 25±5ºC/60±5%RH and 40±5ºC/75±5%RH. Optimized tablets have shown no appreciable changes with respect to taste, disintegration, and dissolution profiles. This work helped in understanding the effect of formulation processing variables especially the subliming agents on the drug release profile. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.

Item Type: Article
Uncontrolled Keywords: Loratadine, in vitro dissolution study,oro-dispersible tablets, camphor,stability study.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 04 Jan 2012 06:35
Last Modified: 04 Jan 2012 06:35

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