Exploring the use of Isomalt as the Tooth friendly sugar Substitute in the Formulation of Salbutamol Sulfate Compressed tablet Lozenges

Kini, Rajesh and Rathnanand, Mahalaxmi and Kamath, Deepak (2011) Exploring the use of Isomalt as the Tooth friendly sugar Substitute in the Formulation of Salbutamol Sulfate Compressed tablet Lozenges. International Journal of PharmTech Research, 3 (3). pp. 1375-1381.

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Abstract

The objective of the present study was to formulate the medicated lozenges of Salbutamol sulphate for paediatric, geriatric and Dysphagic patients and to explore the use of Iso-malt as the sugar substitute in the prepared lozenges. The compressed tablet lozenges were prepared by wet granulation technique from three developed methods like, ordered mixture of drug, from the drug adsorbate of magnesium trisilicate and from the spray dried hybrid mixture of drug and mannitol, using Iso-malt as a sugar substitute, glycerine, citric acid artificial flavours and colours and other essential excipients. The prepared medicated lozenges were characterized for drug content uniformity, tablet hardness, thickness, weight variation, friability and in vitro disintegration and dissolution by pharmaceutical standard methods. Accelerated stability study conducted as per ICH guidelines (zone IV) at 45°C and 75% relative humidity over a period of seven weeks found that there wasn’t any substantial interaction between the drugs, flavor and color and the prepared formulations were stable.

Item Type: Article
Uncontrolled Keywords: Ordered mixture, Spray dried mixture, Isomalt, Magnesium trisilicate adsorbate, MCI lavine buffer.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 04 Jan 2012 06:45
Last Modified: 04 Jan 2012 06:45
URI: http://eprints.manipal.edu/id/eprint/2220

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