Pannala, Srinivas and Rathnanand, Mahalaxmi (2011) Preparation and in vitro Evaluation of Nizatidine immediate release tablets. International Journal of PharmTech Research, 3 (3). pp. 1688-1692. (Submitted)

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Abstract

The objective of the present work is to prepare and evaluate (in vitro) nizatidine immediate release tablets. The developed drug delivery system delivers a programmed dose of drug intended for excessively secreted gastric acid and for promoting healing of duodenal ulcers thereby spontaneously delivering the drug when exposed into GIT for producing an anti-ulcer effect. Accordingly, immediate release drug-containing core tablets of Nizatidine were prepared by wet granulation method. The obtained tablets were evaluated for weight variation, thickness, hardness, drug content, disintegration and in vitro dissolution studies. Stability studies of the optimized formulation was carried out as per ICH guidelines at 40 ± 2oC / 75 ±5% RH for one month and it was found to be stable.

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