Preparation and in vitro Evaluation of Nizatidine immediate release tablets

Pannala, Srinivas and Rathnanand, Mahalaxmi (2011) Preparation and in vitro Evaluation of Nizatidine immediate release tablets. International Journal of PharmTech Research, 3 (3). pp. 1688-1692. (Submitted)

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The objective of the present work is to prepare and evaluate (in vitro) nizatidine immediate release tablets. The developed drug delivery system delivers a programmed dose of drug intended for excessively secreted gastric acid and for promoting healing of duodenal ulcers thereby spontaneously delivering the drug when exposed into GIT for producing an anti-ulcer effect. Accordingly, immediate release drug-containing core tablets of Nizatidine were prepared by wet granulation method. The obtained tablets were evaluated for weight variation, thickness, hardness, drug content, disintegration and in vitro dissolution studies. Stability studies of the optimized formulation was carried out as per ICH guidelines at 40 ± 2oC / 75 ±5% RH for one month and it was found to be stable.

Item Type: Article
Uncontrolled Keywords: Immediate release tablets, Anti-ulcer activity, Wet granulation.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 04 Jan 2012 10:02
Last Modified: 04 Jan 2012 10:02

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