Dry Powder Inhalation Formulations for Pulmonary Drug Delivery

Pandey, Shivanand and Mahalaxmi, R and Devmurari, Viral and Jivani, NP (2009) Dry Powder Inhalation Formulations for Pulmonary Drug Delivery. Journal of Pharmacy Research, 2 (8). pp. 1203-1207.

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Asthma is a pulmonary disease characterized by reversible airway obstruction, airway inflammation, and increased airway responsiveness to a variety of stimuli. Pulmonary delivery of drugs plays an indispensable role in the management of asthma. ß Adrenoceptor agonists and corticosteroids are two common classes of drugs administered via the lungs. Pulmonary drug delivery offers a number of advantages, including: (a) a small amount of drug will normally suffice for preventing or treating symptoms; (b) adverse reactions are usually much less than those produced by systemic administration; and (c) there is a rapid and predictable onset of action. Since the introduction of the first inhaled medication, Datura ferox, a congener of atropine, in England in 1802, the inhalation route of drug delivery has captured increasing attention in the pharmaceutical industry. Inhalation therapy is not limited to asthma, but is also of benefit to other respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and bronchiectasis. Lungs, with a large surface area, good vascularization, an immense capacity for solute exchange and an ultra-thin alveolar epithelium, have been actively explored as an effective route for systemic delivery of peptides and proteins of particular potential in this development is inhaled insulin, which may serve as an effective, well-tolerated, noninvasive alternative to subcutaneous regular insulin. Pulmonary route is considered an important means for both local and systemic drug delivery1.

Item Type: Article
Uncontrolled Keywords: Inhalation therapy, Vasculization, Alveolar epithelium.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 05 Jan 2012 05:47
Last Modified: 05 Jan 2012 05:47
URI: http://eprints.manipal.edu/id/eprint/2226

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