Pulmonary Route as an Important Means of Drug Delivery: Inhalers Provided to Meet our Needs

Pandey, Shivanand and Choudhary , Vasanti and Mahalaxmi, R and Devmurari, Viral and Jivani, NP (2009) Pulmonary Route as an Important Means of Drug Delivery: Inhalers Provided to Meet our Needs. Journal of Pharmacy Research, 2 (8). pp. 1232-1235.

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Abstract

Inhalers are designed to disperse fine, respirable powders in a reproducible fashion for optimal systemic or local lung delivery. Together with our particle technologies, they create an integrated pulmonary delivery system. We also offer expertise in systems integration of pulmonary therapeutics with Metered Dose Inhalers (MDIs), including stable formulations for your drugs a along with propellants. The new hydrofluoroalkane (HFA) propellants and the ability to deliver many molecules more efficiently to the deep lung compared with traditional MDIs1. Dry powder inhalation (DPI) is an important means of pulmonary drug delivery for both local and systemic actions. Since drugs of different solid-state chemistry can influence a wide range of physical, chemical and biological properties, control of the solid-state structures and associated behaviors of drug particles is critical for DPI formulation. Current production technology of fine drug particles for pulmonary delivery utilizes sequential batch crystallization and micronization. However, this two-step manufacturing approach often causes unwanted crystallographic damage to the particles and may induce undesirable polymorphic transformation in certain materials. In recent years, spraydrying and supercritical fluid crystallization have emerged as two cost efficient processing technologies that allow more precise control of the crystal forms and physical properties of the powders produced in a single step operation. This article presents a critical review of these latest technological developments in DPI formulation with focus on the regulation of the physical forms of inhaled drug particles.

Item Type: Article
Uncontrolled Keywords: Inhalers, Propellants, Dry powder inhalation, Micronization.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 09 Jan 2012 10:34
Last Modified: 09 Jan 2012 10:34
URI: http://eprints.manipal.edu/id/eprint/2227

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