Koteshwara, KB and Thoppi, Sowmya C and Naha, Anup (2011) Design and Development of Multiparticulate Drug Delivery of Metronidazole for Targeted Delivery to Colon. International Journal Of Pharmacy&Technology, 3 (4). pp. 3580-3589. (Submitted)

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Abstract

The objective of the present study was to develop and evaluate a multiparticulate drug delivery system for colon targeted delivery of metronidazole. Metronidazole granules were prepared by wet granulation method using Eudragit RSPO followed by enteric coating with Eudragit S100. Solubility studies and drug excipients compatibility studies were carried out. The prepared granules were evaluated for drug content, percentage increase in weight and in vitro drug release. Drug content in all batches varied from 97.95% to 99.14%. All excipients were found to be compatible with the drug. Granules (D) containing 40% Eudragit RSPO showed optimum binding property. A significant difference of %CDR in phosphate buffer (pH 6.8) between the formulations was noticed with the least difference being seen in D4 (20% increase in weight after coating with Eudragit RSPO) as compared to D. (P<0.01). In addition D4 showed a sustained drug release with 98.99 % drug released at the end of 24 hours. Further formulation D4c (15% increase in weight after coating with Eudragit S100) did not or least release the drug (0.4116%) in stomach pH (0.1 N HCL) and upper parts of small intestine pH 6. Studies demonstrated that multiparticulate drug delivery system (D4c) can be used for the targeted delivery of metronidazole to the colon.

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