Design, Optimization and Physical and Chemical Evaluation of Domperidone Pellets

Pandey, Shivanand and Rathanand, Mahalaxmi (2009) Design, Optimization and Physical and Chemical Evaluation of Domperidone Pellets. Journal of Pharmacy Research, 2 (11). pp. 1794-1798. (Submitted)

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Different theories have been postulated related to the mechanism of formation and growth of pellets. Some of these theories are derived from experimental results while others are confined to visual observations results obtained from the experiments with some form of tracer technique are regarded as acceptable and convincing. Domperidone pellets are small, free-flowing, spherical or semi-spherical solid units, typically from about 0.5mm to 1.5mm, and are intended usually for oral administration. They have better solubility than the pure drug itself. The study was undertaken with an aim for formulation optimization and in-vitro evaluation by using sodium Lauryl sulphate at different concentration for increasing the release rate. Organoleptic and preformulation studies were performed initially and results directed for the further course of formulation. Evaluated for tests such as loss on drying, bulk density, and tapped density before being pellets formulation. Pellets were tested for loss on dry, moisture content, bulk density, tapped density, granule density, hauser ratio, carr’s index, angle of repose, size, shape, friability and In-vitro drug release as per pharmacopeial procedure and finally stability studies were performed.

Item Type: Article
Uncontrolled Keywords: Domperidone, Free-flowing, Spherical, Semi-spherical, organoleptic
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 04 Jan 2012 10:25
Last Modified: 04 Jan 2012 10:25

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