Histological changes in the brain of Young fluoride-intoxicated rats

Shivarajashankara, YM and Shivashankara, AR and Bhat, Gopalakrishna P and Rao, Muddanna S and Rao, Hanumanth S (2002) Histological changes in the brain of Young fluoride-intoxicated rats. Fluoride , 35 (1). pp. 12-21.

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Wistar albino rats were exposed to 30 or 100 ppm fluoride (as NaF) in drinking water during their fetal, weanling, and post-weaning stages until the age of ten weeks. Rats exposed to 30 ppm fluoride did not show any notable alterations in brain histology, whereas rats exposed to 100 ppm fluoride showed significant neurodegenerative changes in the hippocampus,amygdala, motor cortex, and cerebellum. Changes included decrease in size and number of neurons in all the regions, decrease in the number of Purkinje cells in the cerebellum, and signs of chromatolysis and gliosis in the motor cortex. These histological changes suggest a toxic effect of high-fluoride intake during the early developing stages of life on the growth, differentiation, and subcellular organization of brain cells in rats.

Item Type: Article
Uncontrolled Keywords: Albino rats, Amygdala, Brain histology, Cerebellum, Fluoride intoxication, Hippocampus, Motor cortex, Neurodegenerative changes, Sodium fluoride
Subjects: Medicine > KMC Manipal > Anatomy
Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 05 Jan 2012 06:53
Last Modified: 05 Jan 2012 06:53
URI: http://eprints.manipal.edu/id/eprint/2234

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