Pandey, Shivanand and Patel, Binal and Mahalaxmi, R and Devmurari , Viral and Jivani, NP (2009) Microneedle: a Effective and Safe Tool for Drug Delivery. International Journal of PharmTech Research, 1 (4).

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Abstract

Microneedle-based vaccination with the current anthrax vaccine produced an equally effective immune response to intramuscular injection in rabbits using smaller dosage say researcher from Maryland and North Carolina. In the study researchers compared the efficacy of immunizing rabbits with the current anthrax vaccine intradermally using a microneedle and intramuscularly using a conventional needle. Results showed that intradermal delivery required less dosage to induce similar antibody levels as those seen following intramuscular injection. Rabbits that were administered the vaccine using the microneedle-based technique showed protection against inhalation anthrax at 100%, while those vaccinated using conventional methods were protected at 71%.

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