Effect of Recrystallization on Size, Shape, Polymorph and Dissolution of Carbamazepine

Mahalaxmi, R and Ravikumar, * and Pandey, Shivanand and Shirwaikar, Arun and Shirwaikar, Annie (2009) Effect of Recrystallization on Size, Shape, Polymorph and Dissolution of Carbamazepine. International Journal of PharmTech Research, 1 (3). pp. 725-732.

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Abstract

The recrystallization of carbamazepine was done by using two solvents and at different cooling conditions.The solvent and cooling conditions could modify the size, shape, polymorph and thereby the dissolution of original drug. The crystal shape of original carbamazepine was flaky or thin plate like. In the present work carbamazepine crystals were modified by using ethanol and acetone under four different cooling conditions. DSC study showed a change in the polymorphs under different conditions of cooling. The samples recrystallized from ethanol and acetone solutions as well as the original CBZ samples exhibited identical IR spectra, indicating that there was no change at the molecular level. A study indicated that the size, shape and the type of polymorphs in the sample effect its dissolution behaviour.

Item Type: Article
Uncontrolled Keywords: Carbamazepine, Recrystallization, Crystals, Polymorphs, dissolution, IR spectra
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Pharmacy > MCOPS Manipal > Pharmacognosy
Depositing User: KMC Manipal
Date Deposited: 05 Jan 2012 05:52
Last Modified: 05 Jan 2012 05:52
URI: http://eprints.manipal.edu/id/eprint/2261

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