Enhancement of Dissolution of Glipizide from Controlled Porosity Osmotic Pump Using a Wicking Agent and a Solubilizing Agent

Mahalaxmi, R and Sastri, Phanidhar and Ravikumar, * and Kalra, Atin and Kanagale, Pritam D and Narkhede, R (2009) Enhancement of Dissolution of Glipizide from Controlled Porosity Osmotic Pump Using a Wicking Agent and a Solubilizing Agent. International Journal of PharmTech Research, 1 (3). pp. 705-711.

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Abstract

Extended release controlled porosity osmotic pump formulations of model drug glipizide were developed using a wicking agent and a solubilizing agent. Glipizide osmotic tablets were evaluated for their flow properties, weight variation, hardness, friability and content uniformity. The effect of different formulation variables like level of wicking agent, solubilizing agent, level of pore former and membrane weight gain on in vitro release were studied. Drug release was found to be affected by the level of wicking agent and solubilizing agent in the core. Glipizide release from controlled porosity osmotic pump was directly proportional to the pore former (sorbitol) and inversely proportional to membrane weight gain. Drug release from the developed formulations was independent of pH and agitational intensity and was dependent on osmotic pressure of the release media. The optimized formulation was also found to stable upon stability studies.

Item Type: Article
Uncontrolled Keywords: Glipizide, Wicking agent, Solubilizing Agent, Osmotic system, Controlled Porosity Osmotic Pump (CPOP)
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 05 Jan 2012 10:55
Last Modified: 05 Jan 2012 10:55
URI: http://eprints.manipal.edu/id/eprint/2265

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