Formulation and Evaluation of Controlled-Release Diltiazem Hydrochloride Buccoadhesive Tablets

Kumar, Ravi and Patil, Sachin and Patil, MB and Paschapur, Mahesh S and Rathnanand, Mahalaxmi (2010) Formulation and Evaluation of Controlled-Release Diltiazem Hydrochloride Buccoadhesive Tablets. Der Pharmacia Lettre, 2 (1). pp. 48-60. ISSN 0974-248X

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Diltiazem HCl (DTZ) is a calcium channel blocker used in the treatment of hypertension and angina (variant & classical angina). Diltiazem HCl was selected as a model drug for investigation because of its suitable properties like half-life of 4.5 hrs, optimum partition coefficient (158) and molecular weight (450.98), was formulated onto buccoadhesive tablets to overcome the limitations in the currently available dosage and routes of administration which in sequence will increase patient’s compliance. Mucoadhesive buccal tablets of Diltiazem hydrochloride were prepared using carbopol-934, Sodium carboxy methyl cellulose (SCMC), Hydroxy propyl methyl cellulose (HPMC) and sodium alginate as mucoadhesive polymers. Ten formulations were developed with varying concentrations of polymers. Each formulated batch was subjected to various evaluation parameters. The physical appearance of buccal patch was examined by scanning electron microscopy. The release behavior was non-Fickian controlled by a combination of diffusion and chain relaxation mechanisms and best fitted zero-order kinetics. All tablets were acceptable with regard to thickness, weight variation, hardness, and drug content. The maximum bioadhesive strength was observed in tablets formulated with a NaCMC followed by CP and CP-NaCMC. Formulation F10 showed maximum release of 79% in 8hours. Formulation F8 showed maximum swelling index of 3.7 after 8hours. Formulation F10 follows zero order drug release. FTIR studies show no evidence on interaction between drug and polymers. The results indicate that suitable mucoadhesive buccal tablets with desired properties could be prepared.

Item Type: Article
Uncontrolled Keywords: Mucoadhesive, Buccal patch, Diltiazem hydrochloride, mechanical properties, in vitro studies, ex vivo studies.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 07 Jan 2012 09:06
Last Modified: 07 Jan 2012 09:06

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