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Fixed Dose Drug Combinations in Therapeutics: An Overview

Eesha, BR and Mohan, L and Satish Kumar, MC and Shankar, PR (2010) Fixed Dose Drug Combinations in Therapeutics: An Overview. The Journal of Medicine Use in Developing Countries, 2 (1). pp. 27-42.

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Abstract

Fixed dose combinations (FDCs) are often used in therapy to minimize pill load and improve compliance. FDCs are a combination of two or more active ingredients in a defined composition. FDCs have major positive and adverse impact on public health. In developing countries they play an important role in treatment of diseases like tuberculosis, HIV/AIDS and malaria. Important criteria have been developed to assess FDCs. Polypharmacy is common in health facilities in developing countries. Polypharmacy has a number of associated problems. FDCs can partly address the problem. Reducing pill load, improving patient compliance by simplifying regimens and reducing cost and chances of resistance are major advantages. FDCs also have disadvantages. The authors look at the use of FDCs in analgesia, infectious diseases, HIV/AIDS, hypertension, contraception, tuberculosis and other diseases. The cardiovascular polypill is also briefly discussed. Irrational FDCs are being marketed in developing countries. The authors specifically discuss the case of India and Nepal

Item Type: Article
Uncontrolled Keywords: Developing countries, Fixed dose combinations, Polypharmacy, Polypill, Public health, Rational use of medicines
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 07 Jan 2012 09:04
Last Modified: 07 Jan 2012 09:04
URI: http://eprints.manipal.edu/id/eprint/2293

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