Effect of fluoride intoxication on lipid Peroxidation and antioxidant systems in rats

Shivarajashankara, YM and Shivashankara, AR and Bhat, Gopalakrishna P and Rao, Hanumanth S (2001) Effect of fluoride intoxication on lipid Peroxidation and antioxidant systems in rats. Fluoride, 34 (2). pp. 108-113.

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Abstract

The effect of fluoride intoxication on lipid peroxidation and antioxidant systems in the blood, brain, and liver of rats was studied. Twelve onemonth-old albino rats were administered 100-ppm fluoride (as NaF) in their drinking water for four months. In the red blood cells the levels of malondialdehyde (MDA) and glutathione (GSH) increased, along with the activity of glutathione peroxidase (GSH-Px), but the activity of superoxide dismutase (SOD)decreased. In the plasma the level of ascorbic acid increased while that of uric acid decreased. In the brain and liver, MDA and GSH levels increased, as did the activities of GSH-Px and glutathione S-transferase (GST). The level of ascorbic acid increased in the brain, but it decreased in the liver. These results suggest that fluoride enhances lipid peroxidation in the red blood cells, brain and liver of rats and causes increased or decreased enzyme activity associated with free radical metabolism.

Item Type: Article
Uncontrolled Keywords: Albino rats, Antioxidants, Ascorbic acid, Fluoride intoxication, Glutathione, Glutathione peroxidase, Glutathione S-transferase, Lipid peroxidation, Sodium fluoride, Superoxide dismutase.
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 07 Jan 2012 06:25
Last Modified: 07 Jan 2012 06:25
URI: http://eprints.manipal.edu/id/eprint/2302

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