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Melatonin, The Hormone of Darkness: A Ray of Hope For Many Diseases

Shankar, PR and Mishra, P and Upadhyay, DK and Lalit, M and Subish, P and Saha, AC (2006) Melatonin, The Hormone of Darkness: A Ray of Hope For Many Diseases. Pharmacologyonline, 2. pp. 274-289.

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Abstract

Melatonin plays a major role in synchronizing internal biologic events to the external environment. The hormone is mainly secreted by the pineal gland. The secretion is regulated by the suprachiasmatic nuclei of the hypothalamus with the light/dark cycle being the main synchronizer. MT1 and MT2 are the two main types of receptors. Melatonin promotes sleep, regulates reproduction, circadian rhythms,immunoresponsiveness and inhibits aging and cancer growth. Melatonin has been shown to be useful in treatment of jet lag and delayed sleep phase syndrome. Treatment of insomnia in the elderly, tapering of hypnotics, treatment of cancer, amelioration of the toxicity of cancer chemotherapy and entraining circadian rhythms in the blind are other indications. Melatonin has been used for preoperative sedation and in eurodegenerative disorders and stroke. The drug has shown promise as a radioprotective agent. Drug-drug interactions can be a problem. Agomelatine and Ramelteon are melatonin receptor agonists and are showing clinical promise. Melatonin and its congeners will play an important role in therapeutics.

Item Type: Article
Uncontrolled Keywords: Agonists, Melatonin, Therapeutic uses
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 09 Jan 2012 04:35
Last Modified: 09 Jan 2012 04:35
URI: http://eprints.manipal.edu/id/eprint/2305

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