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Evaluation of Andrographis paniculata leaves extract for analgesic activity

*, G. Shivaprakash and *, H.N. Gopalakrishna and *, Deepti Sandeep Padbidri and *, Shruthi Sadanand and *, Sahu Sudhanshu Sekhar and Shetty, R. Nivedita (2011) Evaluation of Andrographis paniculata leaves extract for analgesic activity. Journal of Pharmacy Research, 4 (10). pp. 3375-3377. ISSN 0974-6943

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Abstract

Objective: Aqueous extract of Andrographis paniculata leaves was subjected to analgesic activity in animal models. Materials and Methods: The study was carried out in male swiss albino mice weighing 25-30 gm.Analgesic activity of the aqueous extract of Andrographis paniculata leaves at doses 50,100,500mg/ kg p.o was evaluated using two animal models viz.acetic acid induced writhing and Eddy’s hot plate model. Results: Aqueous extract of Andrographis paniculata (AP) at doses 100mg and 500mg/Kg p.o. significantly reduced (P<0.01) acetic acid induced writhing in both acute and chronic study. The test drug at doses 100, 500mg/kg was better than the standard drug aspirin 150mg/kg in acute study.The percent reduction of abdominal constrictions was 20%, 56% and 57% at doses 50, 100 and 500mg/kg p.o. respectively compared to control in acute study. In chronic study the percent reduction of abdominal constriction was 15%, 69.4% and 70.4% at doses 50, 100 and 500mg/kg respectively. The extract increased the reaction time significantly at doses 50, 100 and 500mg/kg p.o in acute study at 15min, 30min and 60 min by Eddy’s hot plate model and maximum increase (P<0.01) was observed at dose 500mg/kg. In chronic study the analgesic activity of the extract was observed at all doses at 15 min and the mean reaction time increased significantly (P<0.001) at dose 500mg/kg at 30 min and diminished later. Conclusion: The results confirm the analgesic activity of Andrographis paniculata by both peripheral and central actions which were comparable to standard drug. The maximum effect was observed at dose 500mg/kg in both the models

Item Type: Article
Uncontrolled Keywords: Analgesic, acetic acid, Andrographis paniculata, Eddy’s hotplate, writhing
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 07 Jan 2012 04:40
Last Modified: 07 Jan 2012 04:40
URI: http://eprints.manipal.edu/id/eprint/2314

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