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A clinical and biochemical study of chronic Fluoride toxicity in children of Kheru Thanda of Gulbarga district, Karnataka, India

Shivashankara, AR and Shivarajashankara, YM and Rao, Hanumanth S and Bhat, Gopalakrishna P (2000) A clinical and biochemical study of chronic Fluoride toxicity in children of Kheru Thanda of Gulbarga district, Karnataka, India. Fluoride, 33 (2). pp. 66-73.

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Abstract

The prevalence of dental and skeletal fluorosis was determined among children of Kheru Nayak Thanda of Gulbarga district, where the fluoride concentration in drinking water ranges from 0.6 to 13.4 ppm and the water has low levels of copper and zinc. These children were investigated clinically, radiologically and biochemically. The study revealed that 89% of the children had dental fluorosis and 39% exhibited skeletal fluorosis. Serum samples of these children showed elevated levels of alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST), and decreased levels of total protein, albumin, and potassium. Radiog raphic changes suggestive of osteoporosis, osteosclerosis, and genu valgum were observed.

Item Type: Article
Uncontrolled Keywords: Fluorosis, Genu valgum, Genu varum, Osteoporosis, Osteosclerosis.
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 10 Jan 2012 07:02
Last Modified: 10 Jan 2012 07:02
URI: http://eprints.manipal.edu/id/eprint/2374

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