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16 - Novel Strategies for the Therapeutic Management of type ii Diabetes

Naik, Anantha Nagappa 16 - Novel Strategies for the Therapeutic Management of type ii Diabetes. Health Administrator, 1 (2). pp. 58-68.

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Abstract

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia arising as a result of a relative or absolute deficiency of Insulin secretion, resistance to insulin action, or both. Diabetes is an ailment in which the body does not produce or properly use insulin. Insulin is a regulatory hormone required for energy management. The cause of diabetes continues to be a anonymity, although both genetics and environmental factors such as obesity and lack of exercise appear to play roles. Diabetes mellitus is a major and growing public health problem throughout the world, with an estimated worldwide prevalence in 2000 of 150 million people, expected to increase to 220 million people by 2010. Numerous reports have documented the sharply increasing incidence of Type II diabetes in the world. Recent estimates project that the number of patients diagnosed with Type II diabetes will more than double to 300 million before 2025. Once found in primarily in middle-aged adults (hence the terminology �“adult onset�” diabetes), the disease is now being observed with increasing frequency in young children and adolescents. This group of patients has been reported to suffer from an increased risk of cardiovascular disease, similar to that observed in adults. Recent advances in understanding insulin secretion, action and signaling have led to the development of new pharmacological agents. In this article, we review new molecules that are promising candidates for the future management of diabetes, focusing on their mechanism of action, efficacy, safety profile and potential benefits compared with pharmacological agents that are available currently.

Item Type: Article
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 12 Jan 2012 11:14
Last Modified: 12 Jan 2012 11:14
URI: http://eprints.manipal.edu/id/eprint/2376

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