Evaluation of Antiinflammatory Activity of Tephrosia purpurea in rats

Shenoy, Smita and Shwetha, K and Prabhu, K and Maradi, Ravindra and Bairy, KL and Shanbhag, T (2010) Evaluation of Antiinflammatory Activity of Tephrosia purpurea in rats. Asian Pacific Journal of Tropical Medicine, 3 (3). pp. 193-195.

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Objective: To evaluate the antiinflammatory activity of orally administered ethanolic extract of Tephrosia purpurea in acute and subacute inflammation in rats. Methods: An ethanolic extract of Tephrosia purpurea was prepared. Carrageenan induced paw edema and cotton pellet granuloma were the models for acute and subacute inflammation respectively. Four groups of rats in each model were treated orally with 2% gum acacia, 100 mg /kg of aspirin, 500 mg/kg and 1 000 mg/kg of ethanolic extract of Tephrosia purpurea respectively. In carrageenan induced paw edema model, subplantar injection of 1% carrageenan was made into the hind paw of the rats sixty minutes after the administration of the respective drugs. The paw volume was measured immediately after injection of carrageenan, at 3 hours and at 6 hours. Then percentage inhibition of edema was calculated. In the cotton pellet granuloma model,animals were administered drugs for six days after placing cotton pellets in the axilla on each side. On the 7th day, dry weight of granuloma was calculated. Results: The rats treated with Tephrosia purpurea did not exhibit any significant decrease in paw volume and serum ceruloplasmin levels as compared to the control and aspirin treated groups in the acute inflammation model; while, there was a significant (P < 0.01) decrease in the weight of granuloma in Tephrosia purpurea and aspirin treated groups as compared to control in subacute inflammation. Conclusions: The ethanolic extract of orally administered Tephrosia purpurea shows significant antiinflammatory effect in subacute inflammation but not in acute inflammation in rats.

Item Type: Article
Uncontrolled Keywords: Tephrosia purpurea,Antiinflammatory activity Oral, Acute inflammation Subacute inflammation
Subjects: Medicine > KMC Manipal > Biochemistry
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 13 Jan 2012 06:05
Last Modified: 05 Nov 2016 09:08
URI: http://eprints.manipal.edu/id/eprint/2404

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