Hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatocellular damage in Wistar albino rats

Eesha, BR and Amberkar, Mohan Babu V and Meena Kumari, K and Sarath babu, * and Vijay, M and Lalit, M and Rajput, R (2011) Hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatocellular damage in Wistar albino rats. Asian Pacific Journal of Tropical Medicine, 4 (6). pp. 466-469.

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Abstract

To evaluate the hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatic damage in rats. Methods: The plant material was shade dried, powdered and extracted with ethanol. Liv 52 and silymarin were used as standard drugs and d2%am gaugme laikcaec AiaS Ta,s AaL cTo, nAtrLoPl a(vnedh ilcipleid). Apletreorxaitdioens iwne trhee t elestveedls, aonf db ipohcyhteomchiceaml imcaalr kteesrtss owf ehreep aaltsioc performed. Results: Paracetamol (2 g/kg) increased the serum levels of alanine minotransfer (TArLeTat),m aesnpta ortfa tLei va m52in, ostirlaynmsaferirnas aen (dA SeTth),a anloklaicli neex tprahcots pohf aTtaesrme i(nAaLlPi)a apnadn itchuel alitpai d(2 p0e0r omxgid/kegs). aelxtterraecdt rleevveealsl eodf tbhieo cphreemseincacle mofa rpkheern aonlidc schoomwpeodu nsidg nainfidc aflna v anepoiadtos.p Orouterc ftiinvdei nacgtsi vsiutyg.g eEsttheadn tohlaict ethanolic bark extract of Terminalia paniculata possessed hepatoprotective activity in a dose dependent manner. Conclusions: Terminalia paniculata possesses hepatoprotective activity. It could be an effective and promising preventive agent against PCT induced hepatotoxicity.

Item Type: Article
Uncontrolled Keywords: Terminalia paniculata PHaerpaacteotparmotoelction SLiilvy m52arin
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 12 Jan 2012 11:12
Last Modified: 27 Oct 2016 09:08
URI: http://eprints.manipal.edu/id/eprint/2446

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