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Simulation Study on Type I Diabetic Patient

Kamath, Surekha and George, V I and Vidyasagar, Sudha (2009) Simulation Study on Type I Diabetic Patient. IETE Journal of Research, 55 (6). pp. 287-293. ISSN 0970-1664

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Abstract

Maintaining glucose concentration in normoglycemic range in Type I diabetic patients is challenging. In this study H` control is applied for insulin delivery to prevent hyperglycemic levels in a type I diabetic patient. From a ­control theory point of view, the blood glucose regulation problem is reformulated as a tracking one. A glucose ­tolerance curve (GTC) validated from several patients is used as a reference model. Intra-and inter-patient variability ­poses a ­challenging task to control blood glucose concentration in diabetic patients. A data based robust controller is ­developed to control blood glucose concentration in type I diabetic patients in the presence of meal disturbances under patient-model mismatch. Simulation studies are performed on the diabetic patient model under feedback ­control which revealed that the proposed control strategy is able to control blood glucose concentration well within the acceptable limits and also compensate for slow parametric drifts.

Item Type: Article
Additional Information: © IETE Journal of Research
Uncontrolled Keywords: Glucose insulin modeling, H∞ control, Insulin dependent diabetic mellitus, Insulin modeling, Mathematical modeling, Robust control.
Subjects: Engineering > MIT Manipal > Instrumentation and Control
Depositing User: MIT Library
Date Deposited: 12 Jan 2012 11:14
Last Modified: 15 Jan 2014 10:18
URI: http://eprints.manipal.edu/id/eprint/2447

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