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Comparative Effect Of Calcium Mupirocin And Fluticasone On Experimentally Induced Brun Wound Healing in Rats

Bairy, KL and Pawan kumar, AV and Holla, Avinash M and Chandrashekar, BR and Lydia, * and Bhavya, B and Satish Kumar, MC (2011) Comparative Effect Of Calcium Mupirocin And Fluticasone On Experimentally Induced Brun Wound Healing in Rats. International Journal of Applied Biology and Pharmaceutical Technology, 2 (2). pp. 140-143.

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Abstract

Topical antibiotic like Calcium mupirocin and its combination with steroid Fluticasone are commonly used to treat burn wounds. But whether they influence healing of wounds is not known. Aim: To compare the effect of Calcium mupirocin and Fluticasone of Apex Laboratories Chennai, on experimentally induced burn wound healing in Wistar rats and compare with available market preparation Mupirocin and Fluticasone -mupirocin combination. Method: Partial thickness burn wound was inflicted, on Wistar rats under ketamine (50mg/kg/i.p) by pouring hot molten wax at 80◦ C into a metal cylinder of 300 mm2 circular opening placed on shaven back of the rat. Animals with partial thickness burn wounds were divided into 7 groups (n=10). Group I did not receive any drug and served as control group. Group II, III, IV, V, VI, and VII received Calcium mupirocin A, Calcium mupirocin B, Mupirocin, Fluticasone+Calcium mupirocin A combination. Fluticasone +Calcium mupirocin B combination and Fluticasone -mupirocin combination creams respectively, twice a day for 21 days or till complete healing whichever was earlier. esults: Calcium mupirocin significantly decreased the duration of epithelialization and increased % of wound contraction in comparison to the control group. This was confirmed by Histopathology studies.

Item Type: Article
Uncontrolled Keywords: Wound healing, Calcium mupirocin, epithelialization. Wound healing, Calcium mupirocin, epithelialization.
Subjects: Medicine > KMC Manipal > Anatomy
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 12 Jan 2012 09:58
Last Modified: 10 Dec 2015 09:13
URI: http://eprints.manipal.edu/id/eprint/2450

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