Sivagurunathan, N and Krishnan, S and Rao, Venkat J and Naik, Anantha Nagappa and Subrahmanyam, VM (2008) Synergy of gatifloxacin with cefoperazone and cefoperazone–sulbactam against resistant strains of Pseudomonas aeruginosa. Journal of Medical Microbiology , 57. pp. 1514-1517.

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Abstract

Chequerboard and time–kill methods were used to compare thein vitro efficacies of thecombinations gatifloxacin (GAT) with cefoperazone (CFP) and GAT with cefoperazone– sulbactam (CFP-SUL) against 58 clinical isolates of Pseudomonas aeruginosa. The combinationsGAT+CFP and GAT+CFP-SUL were shown to be synergistic for 36.2 and 58.6% of isolatestested, respectively, using the chequerboard method. Time–kill studies with 11 strains showedsynergy in 54.5% for the GAT+CFP combination and 72.7% for the GAT+CFP-SULcombination. The agreement between these two methods wasfound to be 72–81 %. There was asignificant difference in synergy between the two combinations tested (P-0.011).

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