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Studies on biogenic amines and their metabolites in mentally retarded children on celastrus oil therapy

Nalini, K and Aroor, AR and Kumar, KB and Rao, Anjali (1986) Studies on biogenic amines and their metabolites in mentally retarded children on celastrus oil therapy. Alternative Medicine, 1 (4). pp. 355-360.

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Abstract

Preliminary studies have shown that celastrus oil improves the learning and memory process in rats, In the present study, the effect of celastrus oil therapy on the learning and memory process in mentally retarded children was studied. Total catecholamines, their metabolites and 5-hydroxy indole acetic acid, which is a metabolite of serotonin, were estimated in the urine samples of 16 mentally retarded children before and after therapy. The results indicated that 6 children were associated with a fall in amines and their metabolites,as compared to the levels before the therapy, with no imporvement in I,Q. the other 6 children showed increased levels of biogenic amines of which 3 children also showed an improvement in general I.Q. However, all the children showed a significant decrease in the excretion of homovanillic acid, a matabolite of dopamine, and VMA. It is concluded that the dopaminergic system is involved in the learning and memory process and also that celastrus oil has a beneficial effect on the learning and memory process in mentally retarded children.

Item Type: Article
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > Psychiatry
Depositing User: KMC Manipal
Date Deposited: 20 Jan 2012 04:43
Last Modified: 20 Jan 2012 04:43
URI: http://eprints.manipal.edu/id/eprint/2481

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