Effect of altered levels of micronutrients on lipid parameters in thyroid dysfunction

Banerjee, Arup K and Joshi, Vivek R and Maradi, Ravindra and Mallick, Ayaz K (2011) Effect of altered levels of micronutrients on lipid parameters in thyroid dysfunction. International Journal of Applied Biology and Pharmaceutical Technology, 2 (4). pp. 235-239.

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Trace elements are extremely important fornormalmetabolism. Copper is one of thetrace metals which has important physiological function in maintaining thyroid activity. Copper isknown to effect lipid metabolism. Increase in serum copper level is associated with decrease in concentration of total cholesterol (TC). Thyroid hormone binding transcription factors, which areessential for modulation of gene expression, contain zinc bound to cysteine residues and alsothyroid hormones influence zinc metabolism by affecting zinc absorption and excretion. Zinc isrequired for enzymes involved in lipid synthesis and lipoprotein excretion. The purpose of thisstudy was to determine the effect of various levels of serum copper and zinc on total cholesterol,plasma triglyceride and low density lipoprotein cholesterol in subjects with thyroid dysfunction. 61subjects were divided into three groups of 13 hypothyroid, 23 hyperthyroid and 25 euthyroid based on thyroid stimulating hormone levels. The correlation between serum copper and low densitylipoprotein (p <0.01) (r = -0.842), serum zinc correlated strongly negative and significantlywith total cholesterol (r= -0.564) , low density lipoprotein cholesterol (r= -0.666) inhyperthyroid group. But the correlation in hypothyroid and euthyroid group differed andwas not significant. Elevated levels of total cholesterol and low density lipoprotein cholesterol may be proatherogenic and increase the risk of cardio vascular diseases hence measures must betaken in correcting and maintaining levels of micronutrients in thyroid dysfunction.

Item Type: Article
Uncontrolled Keywords: Thyroid dysfunction, zinc, copper, lipid parameters, pro-atherogenic,
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 16 Jan 2012 07:06
Last Modified: 16 Jan 2012 07:06
URI: http://eprints.manipal.edu/id/eprint/2492

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