Assessment of serum L-fucose in brain tumor cases

Munjula, S and Monteiro, Flama and Rao, Annaya Aroor and Rao, Suryanarayana and Annaswamy, Raja and Rao, Anjali (2010) Assessment of serum L-fucose in brain tumor cases. Annals of Indian Academy of Neurology , 13 (1). pp. 33-36. ISSN ISSN 0972-2327

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Abstract

BACKGROUND: Glycosylation of altered tumor cell in relation to cellular heterogeneity in human intracranial tumors remains relatively unexposed. Serum protein-bound carbohydrate, L-Fucose is reported to be overexpressed during tumor progression by many investigators. Therefore, there is a need to determine the diagnostic, prognostic, functional significance of glycoprotein elevations in various cases of tumors. OBJECTIVE: The objective of the present study was to evaluate the clinical utility of serum L-fucose in patients with brain tumor. MATERIALS AND METHODS: Serum glyco-conjugate levels were estimated in 99 patients with brain tumors. Estimation of L-fucose was carried out colorimetrically by the method of Winzler using cysteine hydrochloride. RESULTS: There was a significant increase in L-fucose level in most of the patients. In the posttreatment cases, the L-fucose levels were apparently low compared to preoperative values. CONCLUSION: Our results showed that the rise in serum L-fucose may be used as a general marker for brain tumors in addition to other markers.

Item Type: Article
Uncontrolled Keywords: Brain tumors, cysteine hydrochloride, glycosylation,L-Fucose
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > Neurology
Depositing User: KMC Manipal
Date Deposited: 14 Jan 2012 05:01
Last Modified: 14 Jan 2012 05:01
URI: http://eprints.manipal.edu/id/eprint/2509

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