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Altered Dendritic Arborization of Amygdala Neurons in Young Adult Rats Orally Intubated with Clitorea ternatea Aqueous Root Extract

Rai, Kiranmai S and Murthy, Dilip K and Rao, Muddanna S and Karanth, Sudhakar K (2005) Altered Dendritic Arborization of Amygdala Neurons in Young Adult Rats Orally Intubated with Clitorea ternatea Aqueous Root Extract. PHYTOTHERAPY RESEARCH, 19 (7). pp. 592-598.

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Abstract

Young adult (60 day old) Wistar rats of either sex were orally intubated with 50 mg/kg body weight and100 mg/kg body weight of aqueous root extract of Clitoria ternatea(CTR) for 30 days, along with agematched saline controls. These rats were then subjected to passive avoidance tests and the results from these studies showed a significant increase in passive avoidance learning and retention. Subsequent to the passive avoidance tests, these rats were killed by decapitation. The amygdala was processed for Golgi staining and the stained neurons were traced using a camera lucida and analysed. The results showed a significant increase in dendritic intersections, branching points and dendritic processes arising from the soma of amygdaloid neurons in CTR treated rats especially in the 100 mg/kg group of rats, compared with age-matched saline controls. This improved dendritic arborization of amygdaloid neurons correlates with the increased passive avoidance learning and memory in the CTR treated rats as reported earlier. The results suggest that Clitoria ternatea aqueous root extract enhances memory by increasing the functional growth of neurons of the amygdala.

Item Type: Article
Uncontrolled Keywords: Clitoria ternatea; passive avoidance; learning and memory; amygdala neurons; dendritic arborization.
Subjects: Medicine > KMC Manipal > Anatomy
Medicine > MMMC Manipal > Physiology
Medicine > KMC Manipal > Physiology
Depositing User: KMC Manipal
Date Deposited: 14 Jan 2012 04:39
Last Modified: 14 Jan 2012 04:39
URI: http://eprints.manipal.edu/id/eprint/2512

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