Oxidative stress and antioxidants in tubercular meningitis

Sudha, K and Rao, Ashalatha V and Rao, SN and Rao, Anjali (2002) Oxidative stress and antioxidants in tubercular meningitis. Indian Journal of Clinical Biochemistry. , 17 (1). pp. 34-41.

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Oxidative stress is implicated in etiopathogenesis of a variety of human diseases. Therefore, in the present study, erythrocyte lipid peroxidation, percentage hemolysis, antioxidant enzymes viz., glutathione reductase, glutathione peroxidase, superoxide dismutase and plasma antioxidants viz., ceruloplasmin, vitamins A,E and C have been determined in 19 patients with tubercular meningitis (TBM) and 50 normals. Six patients who were treated with antibiotics were considered for the follow up. The statistical analysis was carried out be Mann Whitney U test and Wilcoxon rank sum test. Lipid peroxidation (P<0.02), percentage hemolysis (P<0.001) and plasma ceruloplasmin (P<0.0001) of TBM patients were significantly higher, whereas erythrocyte glutathione reductase (P<0.05) and plasma antioxidant vitamins A,E and C (P<0.01, P<0.05 respectively) were significantly lower than those of the controls. In the follow up patients the glutathione reductase and catalase levels were significantly high (P<0.05) compared to their pre-treated condition. Vitamin C and E levels have attained normal range. This study indicated that the blood antioxidant status of TBM patients which was low compared to controls improved after treatment, suggesting the role of free radicals in TBM.

Item Type: Article
Uncontrolled Keywords: Antioxidant enzymes, antioxidant vitamins, lipid peroxidation, tubercular meningitis.
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > Neurology
Depositing User: KMC Manipal
Date Deposited: 16 Jan 2012 09:36
Last Modified: 16 Jan 2012 09:36
URI: http://eprints.manipal.edu/id/eprint/2516

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