Neurogenic Potential of Clitoria ternatea Aqueous Root Extract – A Basis for Enhancing Learning and Memory

Rai, Kiranmai S (2010) Neurogenic Potential of Clitoria ternatea Aqueous Root Extract – A Basis for Enhancing Learning and Memory. World Academy of Science, Engineering and Technology, 70. pp. 237-242.

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Abstract

The neurogenic potential of many herbal extracts used in Indian medicine is hitherto unknown. Extracts derived from Clitoria ternatea Linn have been used in Indian Ayurvedic system of medicine as an ingredient of “Medhya rasayana”, consumed for improving memory and longevity in humans and also in treatment of various neurological disorders. Our earlier experimental studies with oral intubation of Clitoria ternatea aqueous root extract (CTR) had shown significant enhancement of learning and memory in postnatal and young adult Wistar rats. The present study was designed to elucidate the in vitro effects of 200ng/ml of CTR on proliferation, differentiation and growth of anterior subventricular zone neural stem cells (aSVZ NSC’s) derived from prenatal and postnatal rat pups. Results show significant increase in proliferation and growth of neurospheres and increase in the yield of differentiated neurons of aSVZ neural precursor cells (aSVZNPC’s) at 7 days in vitro when treated with 200ng/ml of CTR as compared to age matched control. Results indicate that CTR has growth promoting neurogenic effect on aSVZ neural stem cells and their survival similar to neurotrophic factors like Survivin, Neuregulin 1, FGF-2, BDNF possibly the basis for enhanced learning and memory.

Item Type: Article
Uncontrolled Keywords: Anterior subventricular zone (aSVZ) neural stem cell, Clitoria ternatea, Learning and memory, Neurogenesis.
Subjects: Medicine > KMC Manipal > Physiology
Depositing User: KMC Manipal
Date Deposited: 16 Jan 2012 09:33
Last Modified: 16 Jan 2012 09:33
URI: http://eprints.manipal.edu/id/eprint/2518

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