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Role of antioxidant enzymes in brain tumours

Rao, Gayathri M and Rao, Ashalatha V and Raja, Annaswamy and Rao, Suryanarayana and Rao, Anjali (2000) Role of antioxidant enzymes in brain tumours. Clinica Chimica Acta (296). pp. 203-212.

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Abstract

Erythrocyte antioxidant enzymes were analysed in 100 patients with intracranial neoplasm and in 47 controls. There was a significant dcrease in RBC glutathione reductase (GRx) and superoxide dismutase (SOD) activity in most types of brain tumor cases. Patients with acoustic neurinoma showed a significant reduction in selenium-dependent glutathione peroxidase (Se-GPx) activity. A decrease in catalase (CT) activity was seen in most of the brain tumor patients but remained statistically insignificant when compared to controls. A significant increase in plasma ceruloplasmin concentration was observed in patients with glioma. These enzymes were also studied in 27 post-treatment cases. GRx activity returned to normal levels in these patients. RBC SOD and plasma ceruloplasmin levels showed a tendency to return to normal. Hence, a marked decrease in the antioxidant enzymes may have a role in the genesis of considerable oxidative stress in patients with brain tumors.

Item Type: Article
Uncontrolled Keywords: Antiozidant enzymes Ceruloplasmin Brain tumors
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > Neurology
Depositing User: KMC Manipal
Date Deposited: 20 Jan 2012 05:02
Last Modified: 20 Jan 2012 05:02
URI: http://eprints.manipal.edu/id/eprint/2521

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