MU Digital Repository
Logo

Effects of celastrus paniculatus on passive avoidance performance and biogenic amine turnover in albino rats

Nalini, K and Karanth, KS and Rao, A and Aroor, AR (1995) Effects of celastrus paniculatus on passive avoidance performance and biogenic amine turnover in albino rats. Journal of Ethnopharmacolgy , 47 (2). pp. 101-108.

[img] PDF
AR25.pdf - Published Version
Restricted to Registered users only

Download (2MB) | Request a copy

Abstract

The effects of an indigenous drug, Celastrus oil, extracted from the seeds of Celastrus paniculatus on learning and memory in a two compartment passive avoidance task was studied in albino rats. The effects on the contents of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) in the brain and on the levels of their metabolites both in the brain and urine were also assessed. Significant improvement was observed in the retention ability of the drug treated rats compared with the saline administered controls. The contents of NE, DA and 5-HT and their metabolites in the brain were significantly decreased in the drug treated group. The urinary metabolite levels were also significantly decreased except for total 3-methoxy-4-hydroxyphenyl glycol. These data indicate that Celastrus oil causes an overall decrease in the turnover of all the three central monoamines and implicate the involvement of these aminergic systems in the learning and memory process.

Item Type: Article
Uncontrolled Keywords: Celastrus paniculatus; Two compartment passive avoidance; Norepinephrine; Dopamine;Serotonin
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 16 Jan 2012 04:19
Last Modified: 16 Jan 2012 04:19
URI: http://eprints.manipal.edu/id/eprint/2532

Actions (login required)

View Item View Item