Changes in glycated proteins during impaired glucose tolerance

Rao, Pragna and Kumar, Anuradha and Rau, NR and Pattabiraman, TN (1990) Changes in glycated proteins during impaired glucose tolerance. Indian Journal of Clinical Biochemistry , 5 (2). pp. 117-122.

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Abstract

In persons with impaired glucose tolerance, serum glycated proteins (9.44±1.46μg hexose/mg protein) increased 1.69-fold (P<0.001) over control subjects compared to an increase of 1.95-fold in overt diabetics. However, correlations between serum glycated protein values and 2 h blood sugar values during the tolerance test (r=0.39) and between the former and graph area (r=0.30) were not strong. Glycated albumin (2.25 mol hexose/mol protein) and glycated haemoglobin (0.398±0.07 mol hexose/mol protein) in the study group also showed 1.67 and 1.24-fold increase respectively compared to controls. Fairly good correlations between glycated serum protein and glycated albumin (r=0.50) and glycated haemoglobin (r=0.45) were observed during this study. The data suggest that measurement of glycated proteins will be a useful index to detect impaired glucose tolerance.

Item Type: Article
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > Medicine
Depositing User: KMC Manipal
Date Deposited: 16 Jan 2012 04:21
Last Modified: 16 Jan 2012 04:21
URI: http://eprints.manipal.edu/id/eprint/2540

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