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Effects of piracetam on retention and biogenic amine turnover in albino rats

Nalini, K and Karanth, KS and Rao, A and Aroor, AR (1992) Effects of piracetam on retention and biogenic amine turnover in albino rats. Pharmacology Biochemisty and Behavior, 42 (4). pp. 859-864.

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Abstract

The chronic effects of orally administered 2-pyrrolidone acetamide (piracetam) on one-trial, passive avoidance task were studied in albino rats. The effects on the contents of norepinephrine (NE), dopamine (DA), and serotonin (5-HT) in the brain and on the levels of their metabolites both in the brain and urine were also assessed. Significant improvement was observed in the retention ability compared with saline-administered controls. The contents of NE, DA, and 5-HT and their metabolites in the brain were significantly decreased after piracetam administration. The urinary metabolite levels were also significantly decreased except total 3-methoxy-4-hydroxyphenyl glycol (MHPG). These data indicate that piracetam causes an overall decrease in the turnover of central monoamines. Thus, the results of this study implicate the involvement of NE, DA, and 5-HT systems in learning and memory processes. Piracetam did not exert any GABAergic effect as shown by the absence of change in the brain GABA levels.

Item Type: Article
Uncontrolled Keywords: Piracetam Passive avoidance Norepinephrine Dopamine Serotonin GABA
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 16 Jan 2012 06:51
Last Modified: 16 Jan 2012 06:51
URI: http://eprints.manipal.edu/id/eprint/2551

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