Wound healing activity of NOE-aspirin: A pre-clinical study

Kaushal, Mandeep and Kutty, Gopalan N and Rao, Mallikarjuna C (2007) Wound healing activity of NOE-aspirin: A pre-clinical study. Nitric Oxide, 16 (1). pp. 150-156.

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Abstract

Aspirin, one of the oldest non-steroidal anti-inXammatory drugs, impedes tissue repair by virtue of retarding nXammation. The present study was undertaken to Wnd out if linking of nitrooxyethyl ester to aspirin reverses its healing-depressant propensity. Nitrooxyethyl ester of spirin (NOE-Asp) was synthesized in our laboratory through well-established synthetic pathway, starting from aspirin through esteriWcation with ethylene glycol and nitration with a mixture of nitric and sulfuric acids at 0 °C. The eVect of NOE-Asp on phases of healing such as ollagenation, wound contraction and epithelialization and on scar size of healed wound was evaluated in three wound models—incision, dead space, and excision wounds. To assess its inXuence on the oxidative stress, the levels of lutathione (GSH) and thiobarbiturate reactive species (TBARS) were also determined in 10-day-old granulation tissue. NOE-Asp was further screened for its anti-inXammatory activity in rat paw edema model. NOE-Asp promoted collagenation (increase in breaking strength, granulation weight, and collagen content), wound ontraction, and epithelialization phases of healing. NOE-Asp also showed a signiWcant antioxidant eVect in 10-day-old granulation tissue as compared to aspirin. The results vindicate our assumption that the esteriWcation of aspirin with nirooxyethyl group reverses the healing-suppressant eVect of aspirin. The compound also showed equipotent anti-inXammatory activity as aspirin.

Item Type: Article
Uncontrolled Keywords: Nitrooxyethyl; Aspirin; Nitric oxide; Wound healing
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 20 Jan 2012 06:59
Last Modified: 20 Jan 2012 06:59
URI: http://eprints.manipal.edu/id/eprint/2565

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