Oxidative stress in pediatric nephrotic syndrome

Kamireddy, Rajani and Kavuri, Suchitra and Sri Devi, * and Vemula, Harathi and Devi, Chandana and Harinarayanan, Salini and James, Reena and Rao, Anjali (2002) Oxidative stress in pediatric nephrotic syndrome. Clinica Chimica Acta, 325 (1-2). pp. 147-150.

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Abstract

BACKGROUND: Nephrotic syndrome (NS) is a stressful condition for children where oxidative damage would also influence the response of these patients to therapy. METHODS: The present study was conducted in children with nephrotic syndrome during relapse and remission and in 10 age- and sex-matched healthy volunteers. Red cell glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA) concentrations as well as plasma ceruloplasmin (CP) and vitamin E concentrations were analyzed in controls and in patients. RESULTS: Erythrocyte superoxide dismutase concentrations were significantly increased in both the groups when compared to controls. Erythrocyte glutathione significantly decreased in nephrotic syndrome in remission along with plasma vitamin E concentrations in both the groups. A significant increase in plasma ceruloplasmin was observed in cases in remission. However, no significant change was observed in the concentrations of erythrocyte malondialdehyde. CONCLUSION: Thus, antioxidant concentrations change considerably, indicating a compensatory mechanism to cope up with increased pro-oxidant status in such cases.

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