An appraisal of the healing profiles of oral and external (GEL) metronidazole on partial thickness burn wounds

Rao, Mallikarjuna C and George, Mathew K and Bairy, KL and Somayaji, SN (2000) An appraisal of the healing profiles of oral and external (GEL) metronidazole on partial thickness burn wounds. Indian Journal of Pharmacology , 32 (5). pp. 282-287.

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Objective: To assess the influence of oral and topical (gel) metronidazole on partial thickness thermal burn wound healing. Methods: Partial thickness burn wounds were produced on dorsum of rats by pouring hot molten wax at 80oC. Oral and two topical gel (MGEL-1and MGEL-2) preparations of metronidazole or their corresponding vehicles were administered to different groups of wound bearing animals. The effects of the treatments were compared by periodically observing wound contraction and epithelization and histological features as indicative of the progress of healing. Results: Healing of burn wounds was significantly promoted by oral metronidazole (p<0.01) and the gel base of MGEL-2. In contrast, the MGEL-1 significantly (p<0.05) depressed the epithelization process while its base was without effect, indicating that topical metronidazole retards healing. The effect of MGEL-2 appeared to be an algebraic sum of pro- and anti-healing effects of the base and drug respectively more in favour of the base (p<0.05). Conclusion: Metronidazole orally promotes but topically depresses healing of burn wounds. The latter effect can be reversed if the base has pro-healing property.

Item Type: Article
Uncontrolled Keywords: Burn wounds healing metronidazole wound contraction epithelization
Subjects: Medicine > KMC Manipal > Anatomy
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 20 Jan 2012 09:42
Last Modified: 20 Jan 2012 09:42

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